|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1989-5-19
|
|
pubmed:abstractText |
To investigate cross-colonization with and persistence of Pseudomonas aeruginosa in cystic fibrosis (CF), 181 isolates from 76 CF patients were typed using a P. aeruginosa-specific DNA probe. Whereas sibling pairs predominantly harboured genotypically identical P. aeruginosa strains, all of the other patients harboured different strains. Seventy-nine per cent (22/31) of the infected CF patients harboured the same strains at the beginning and the end of a summer camp. A change of strains was seen in 10% (3/31) of the patients at the end of the camp. Forty-six per cent (6/13) of the patients who were apparently initially uninfected, acquired P. aeruginosa by the end of the period. Genotyping proved that strain change or acquisition was due to cross-colonization in four of nine cases. Very little P. aeruginosa was isolated from the inanimate environment. Persistence of P. aeruginosa after a temporary loss due to antibiotic therapy was seen in 12/16 paired patient strains before and after antibiotic therapy. Thus, suppression followed a flare-up seemed to occur in these patients rather than eradication and a new infection. When 35 patients were followed over a period of 6 months, 7 (20%) changed the strain in their sputum. Only one of 43 patients harboured two different P. aeruginosa strains simultaneously over a long period.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-107186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-13637915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-2455640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-2880893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3009329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3081597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3086274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3098862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3309236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3313220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3723240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3928491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-3932947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-6126629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-6190882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-6404993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-6413411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-6808106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-7446125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-779549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-809484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-812335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2495226-819641
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0950-2688
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
102
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
205-14
|
|
pubmed:dateRevised |
2010-9-7
|
|
pubmed:meshHeading |
pubmed-meshheading:2495226-Adolescent,
pubmed-meshheading:2495226-Adult,
pubmed-meshheading:2495226-Ambulatory Care Facilities,
pubmed-meshheading:2495226-Antibodies, Bacterial,
pubmed-meshheading:2495226-Child,
pubmed-meshheading:2495226-Child, Preschool,
pubmed-meshheading:2495226-Cross Infection,
pubmed-meshheading:2495226-Cystic Fibrosis,
pubmed-meshheading:2495226-DNA Probes,
pubmed-meshheading:2495226-Family Health,
pubmed-meshheading:2495226-Genotype,
pubmed-meshheading:2495226-Germany, West,
pubmed-meshheading:2495226-Humans,
pubmed-meshheading:2495226-Pseudomonas Infections,
pubmed-meshheading:2495226-Pseudomonas aeruginosa,
pubmed-meshheading:2495226-Radioimmunoassay,
pubmed-meshheading:2495226-Respiratory Tract Infections
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Pseudomonas aeruginosa cross-colonization and persistence in patients with cystic fibrosis. Use of a DNA probe.
|
|
pubmed:affiliation |
Hygiene Institute, University of Tübingen, Federal Republic of Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
