|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0028158,
umls-concept:C0031809,
umls-concept:C0033262,
umls-concept:C0131176,
umls-concept:C0150312,
umls-concept:C0178499,
umls-concept:C0205246,
umls-concept:C0205369,
umls-concept:C0243072,
umls-concept:C0243125,
umls-concept:C0599956,
umls-concept:C0699900,
umls-concept:C1626935
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1991-8-23
|
|
pubmed:abstractText |
The conversion of N-(hydroxymethyl)phthalimide (NHPH) to phthalimide could not be detected within 300 s at pH 9.0, whereas in 0.18 M NaOH complete conversion of NHPH to phthalimide was observed within 50 s. In the presence of 0.2-0.4 M 1,4-diazabicyclo[2.2.2]octane buffer solutions (pH 9.30-9.54), 40-60% conversion of NHPH to phthalimide occurred within 90-120 s. The initial concentration of NHPH affected the extent of conversion of NHPH to phthalimide.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0731-7085
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
685-91
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Aqueous degradation of N-(hydroxymethyl)phthalimide in the presence of specific and general bases. Kinetic assessment of N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs.
|
|
pubmed:affiliation |
Department of Chemistry, Bayero University, Kano, Nigeria.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
