Linked Life Data

2488771

Source:http://linkedlifedata.com/resource/pubmed/id/2488771

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-5-15
pubmed:abstractText
The current work was undertaken in order to assess the role of the monoclonal antibodies (Mabs) to lipopolysaccharide (LPS) of Salmonella typhi in the induction of passive protection against the challenge with the bacteria in a mice model. BALB/c mice were immunized with the whole bacteria, mice with high anti-LPS antibody titers were killed, the spleens were removed and splenocytes were fused with the mouse plasmocytoma SP2/0. Two IgM monoclonal antibodies against porins were developed. Each one of these Mabs recognized the polysaccharide region of LPS. Passive immunization with supernatant fluid of mice with one of these monoclonal antibodies did not protect against challenged with 20 LD50 and 100 LD50 of Salmonella typhi. The results suggest that LPS is not valuable immunogen for the induction of a protective status against typhoid fever.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0066-6769
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Monoclonal antibodies against the lipopolysaccharide of Salmonella typhi 9,12,VI:d. Analysis of passive protection in a mouse model of typhoid fever].
pubmed:affiliation
Laboratorio de Inmunoquímica, Unidad de Investigación Biomédica, CMN, México, D. F.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't