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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1990-7-12
|
| pubmed:abstractText |
Highly oncogenic adenovirus type 12 (Ad12) transformed rat cells contain decreased levels of cytoplasmic and nuclear major histocompatibility (MHC) class I transcripts, a process dependent on the presence of the Ad12 E1A oncogene. Here we show that the reduction in MHC expression is due at least in part to a decreased rate of initiation of transcription of MHC class I genes. Gamma-interferon treatment of Ad12 transformed cells causes an elevation in steady-state levels of cytoplasmic MHC class I transcripts.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
483-7
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2484015-Adenoviruses, Human,
pubmed-meshheading:2484015-Animals,
pubmed-meshheading:2484015-Blotting, Northern,
pubmed-meshheading:2484015-Cell Line,
pubmed-meshheading:2484015-Cell Transformation, Neoplastic,
pubmed-meshheading:2484015-Gene Expression Regulation,
pubmed-meshheading:2484015-Genes, MHC Class I,
pubmed-meshheading:2484015-Interferon-gamma,
pubmed-meshheading:2484015-Poly A,
pubmed-meshheading:2484015-RNA,
pubmed-meshheading:2484015-RNA, Messenger,
pubmed-meshheading:2484015-Rats,
pubmed-meshheading:2484015-Transcription, Genetic
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Regulation of major histocompatibility class I gene expression at the level of transcription in highly oncogenic adenovirus transformed rat cells.
|
| pubmed:affiliation |
Department of Biochemistry, University of Leeds, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|