Linked Life Data

2482213

Source:http://linkedlifedata.com/resource/pubmed/id/2482213

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1990-2-23
pubmed:abstractText
A 72% reduction in the number of premature ventricular complexes, a 75 and 65% reduction in pairs and repetitive forms, respectively, are commonly accepted criteria for the evaluation of the efficacy of short-term antiarrhythmic treatment. On the other hand, a three-to-ten fold increase in the frequency of premature ventricular complexes is considered as a proarrhythmic effect. The aim of this paper is to verify if these criteria can still be applied on a long-term basis. Twenty-eight subjects without a demonstrable underlying organic heart disease and 21 patients with stable chronic ischaemic heart disease were studied. All patients showed more than 30 premature ventricular complexes per hour during ambulatory electrocardiogram monitoring. The spontaneous long term variability of ventricular arrhythmias was evaluated by comparing the first of three consecutive 24-hour ambulatory ECGs at the beginning of the study with a 24-hour ECG monitoring at the end of a 24-month follow-up period. According to the previous criteria about 50% of patients showed a spontaneous reduction in the number of premature ventricular complexes (greater than 72%) mimicking a therapeutic effect if any drug had been given. The increase in ventricular arrhythmias mimicked a proarrhythmic effect in almost 10% of patients. This trend is substantially the same both in subjects without organic heart disease and in patients with chronic coronary artery disease. The results of this study demonstrate that the initially established criteria used to judge the efficacy or the proarrhythmic effect of a given drug cannot be relied upon on a long-term basis.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0046-5968
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
908-12
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Long-term variability in unsustained ventricular arrhythmias: pharmacologic and pro-arrhythmic effect].
pubmed:affiliation
Cattedra di Cardiologia, Università degli Studi di Torino.
pubmed:publicationType
Journal Article, English Abstract