|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1990-2-22
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|
pubmed:abstractText |
By using target cells that expressed only the regulatory NEF protein of the human immunodeficiency virus (HIV), we were able to identify specific cytolytic T cells (CTL) from most of the seropositive patients tested. This NEF-specific cytolytic activity was mediated by CD8+ lymphocytes. In two different donors, we identified a unique peptide in the NEF protein that could be recognized in association with two different HLA class I molecules. The definition of such a peptide should prove useful in evaluating vaccine strategies.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
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|
pubmed:issn |
0014-2980
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pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2383-6
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|
pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2481593-Amino Acid Sequence,
pubmed-meshheading:2481593-Epitopes,
pubmed-meshheading:2481593-Gene Products, nef,
pubmed-meshheading:2481593-HIV Antigens,
pubmed-meshheading:2481593-HIV Seropositivity,
pubmed-meshheading:2481593-HIV-1,
pubmed-meshheading:2481593-HLA-B Antigens,
pubmed-meshheading:2481593-Humans,
pubmed-meshheading:2481593-Immunity, Cellular,
pubmed-meshheading:2481593-Molecular Sequence Data,
pubmed-meshheading:2481593-Peptide Fragments,
pubmed-meshheading:2481593-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2481593-Viral Regulatory and Accessory Proteins,
pubmed-meshheading:2481593-nef Gene Products, Human Immunodeficiency Virus
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
An antigenic peptide of the HIV-1 NEF protein recognized by cytotoxic T lymphocytes of seropositive individuals in association with different HLA-B molecules.
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|
pubmed:affiliation |
INSERM U 152-CNRS 628, Hôpital Cochin, Paris, France.
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pubmed:publicationType |
Journal Article,
In Vitro
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