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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1990-1-22
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pubmed:abstractText |
5'-N-ethylcarboxamideadenosine (NECA) greater than 2-chloroadenosine greater than adenosine greater than N6-(R-phenyl-isopropyl)-adenosine (R-PIA) inhibited in vitro anti-IgE-induced histamine and peptide leukotriene C4 (LTC4) release from human basophils in a concentration-dependent fashion. Micromolar concentrations of adenosine, NECA and R-PIA potentiated the anti-IgE-stimulated release of histamine and LTC4 from human lung parenchymal mast cells. Submillimolar concentrations of adenosine, NECA and R-PIA inhibited in a concentration dependent manner the release of histamine and prostaglandin D2 (PGD2) from skin mast cells challenged with anti-IgE. These results demonstrate marked heterogeneity of the modulatory effect exerted by adenosine on mediator release from human basophils and mast cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1745-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2480501-2-Chloroadenosine,
pubmed-meshheading:2480501-Adenosine,
pubmed-meshheading:2480501-Adenosine-5'-(N-ethylcarboxamide),
pubmed-meshheading:2480501-Adult,
pubmed-meshheading:2480501-Basophils,
pubmed-meshheading:2480501-Histamine Release,
pubmed-meshheading:2480501-Humans,
pubmed-meshheading:2480501-Immunoglobulin E,
pubmed-meshheading:2480501-Lung,
pubmed-meshheading:2480501-Mast Cells,
pubmed-meshheading:2480501-Phenylisopropyladenosine,
pubmed-meshheading:2480501-Prostaglandin D2,
pubmed-meshheading:2480501-SRS-A,
pubmed-meshheading:2480501-Skin,
pubmed-meshheading:2480501-Vasodilator Agents
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pubmed:year |
1989
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pubmed:articleTitle |
Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion.
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pubmed:affiliation |
Department of Medicine University of Naples, Second School of Medicine, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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