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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1989-10-24
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pubmed:abstractText |
Natural antiviral activity can be mediated by the interferon-induced synthesis of 2',5'-oligoadenylates (2-5As) and subsequent RNase L activation by these molecules. Analogues of 2-5A that are biologically active and metabolically stable were synthesized and analyzed for antiviral activity against the human immunodeficiency virus type 1 (HIV-1). Replacement of the 3' hydroxyl group of the adenosine moieties of 2-5A with hydrogen atoms (i.e., cordycepin analogues of 2-5A) converted authentic 2-5A trimer into anti-HIV-1 agents in vitro. These cordycepin analogues of 2-5A also inhibited partially purified HIV-1 reverse transcriptase. Introduction of chirality into the 2',5'-phosphodiester internucleotide linkages or 5'-phosphate moieties of the 2-5A molecule (i.e., phosphorothioate analogues of 2-5A) converted authentic 2-5A into more potent inhibitors of HIV-1 reverse transcriptase. However, these phosphorothioate 2-5As demonstrated little or no anti-HIV-1 activity in vitro. Thus, some analogues of 2-5A may form a class of anti-HIV-1 drugs with possible pleiotropic activities that include activation of latent RNase L and inhibition of reverse transcription.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-217683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-2409414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-2413364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-2413459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-2418504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-2439079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-2968777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3006077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3106982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3258602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3299092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3422647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3427062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3427063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3427064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3499613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-3825401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-4316300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-4316301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-6180680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-6200935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-6275274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-6328660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-6862016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476814-7231556
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7191-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro.
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pubmed:affiliation |
Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN 37232.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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