Linked Life Data

2476203

Source:http://linkedlifedata.com/resource/pubmed/id/2476203

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-10-17
pubmed:abstractText
5-Hydroxyindoleacetic acid (5-HIAA) is the chief end-product of serotonin metabolism. The gastrointestinal tract is the main source of urinary 5-HIAA. The rest originates from the degradation of brain or platelet serotonin stores. Main abnormalities in 5-HIAA excretion have been observed in carcinoid tumors (elevation) or hyperphenylalaninemia (diminution) as well as in migraine. Estimation of renal blood flow is a new application of 5-HIAA measurements. This stems from the elimination process of this weak organic acid which combines glomerular filtration and proximal tubular secretion. Thus 5-HIAA is extracted by the kidney in high amounts as indicated by a high renal extraction ratio. The renal clearance of 5-HIAA seems a good estimation of renal blood flow. Therefore fluctuations of this endogenous compound could be used to quantify the effects of physiological manipulations or drugs on renal blood flow.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0037-9026
pubmed:author
pubmed:issnType
Print
pubmed:volume
183
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[5-HIAA: perspectives in nephrology].
pubmed:affiliation
Laboratoire de Pharmacologie, INSERM U7, Faculté de Médecine Necker-Enfants Malades, Paris.
pubmed:publicationType
Journal Article, English Abstract