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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1989-8-30
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pubmed:abstractText |
A mutant of Escherichia coli K-12 which produces a new outer membrane protein, OmpG, was isolated and genetically and biochemically characterized. The presence of OmpG allows growth on maltodextrins in the absence of the LamB maltoporin. The data obtained from in vivo growth and uptake experiments suggested that the presence of the OmpG protein results in an increase in outer membrane permeability for small hydrophilic compounds. In light of these findings, we suggest that OmpG is a porinlike protein. The mutation which results in the expression of OmpG has been termed cog (for control of OmpG) and mapped to 29 min on the E. coli chromosome. Diploid analysis shows that the mutant cog-192 allele is recessive for both the Dex+ and OmpG+ phenotypes. We propose that the cog mutation destroys a negative regulatory function and therefore derepresses ompG expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-2457014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-2463371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-2580220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-2828311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-2849372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-2984173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-3013502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-3017988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-3276691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-328166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-328489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-346560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-357416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-390313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-4609976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6217397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6281230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6337630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6445892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6448927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6757670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6989640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-6995425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-7021856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-773686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473977-781293
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4105-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
A novel mutation, cog, which results in production of a new porin protein (OmpG) of Escherichia coli K-12.
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pubmed:affiliation |
Department of Biology, Princeton University, New Jersey 08544-1014.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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