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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10-11
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pubmed:dateCreated |
1989-6-15
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pubmed:abstractText |
The effect of drugs on eicosanoid production and on the development of atherogenic index was investigated in canine myocardial ischemia. Iloprost, verapamil, the trapidil derivative AR 12463 or 0.9% NaCl solution were administered 60 min after coronary artery ligation in anaesthetized dogs. Both iloprost and AR 12463 reduced the thromboxane A2/prostacyclin (TXA2/PGI2) ratio in coronary sinus plasma in comparison to controls. The atherogenic index was significantly decreased in the iloprost as well as in the AR 12463-treated group in comparison to the control group. Verapamil had no influence on the investigated parameters.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0232-766X
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pubmed:author |
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|
pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S149-52
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2470353-Animals,
pubmed-meshheading:2470353-Antihypertensive Agents,
pubmed-meshheading:2470353-Arteriosclerosis,
pubmed-meshheading:2470353-Biological Markers,
pubmed-meshheading:2470353-Coronary Disease,
pubmed-meshheading:2470353-Dogs,
pubmed-meshheading:2470353-Epoprostenol,
pubmed-meshheading:2470353-Female,
pubmed-meshheading:2470353-Iloprost,
pubmed-meshheading:2470353-Male,
pubmed-meshheading:2470353-Pyrimidines,
pubmed-meshheading:2470353-Reference Values,
pubmed-meshheading:2470353-Thromboxane A2,
pubmed-meshheading:2470353-Trapidil
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pubmed:year |
1988
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pubmed:articleTitle |
Influence of drugs on the TXA2/PGI2 balance and on the atherogenic index in myocardial ischemia in dogs.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
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pubmed:publicationType |
Journal Article
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