Linked Life Data

2468078

Source:http://linkedlifedata.com/resource/pubmed/id/2468078

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-5-23
pubmed:abstractText
The glucocorticoid-inducible LTL gene [Cell 38:29-38 (1984)] was used as a model target to evaluate preferential drug effects on gene expression. Specifically, the potential of bleomycin, neocarzinostatin, and actinomycin D to induce alterations in either transcriptional or posttranscriptional gene expression was assessed. A Northern blot analysis was used to measure transcriptional effects, whereas changes in posttranscriptional expression were determined through an enzymatic assay for the thymidine kinase product of the LTL gene. Comparisons of the results from these assays with results obtained from assays that evaluated drug effects on cellular RNA and protein synthesis showed that none of the drugs were capable of inducing preferential effects on transcription. However, selective drug-induced effects on the expression of thymidine kinase activity were observed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0026-895X
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-42
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Use of an inducible hybrid viral gene as a model for evaluating drug effects on gene expression.
pubmed:affiliation
Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, New York 14263.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't