Linked Life Data

2465514

Source:http://linkedlifedata.com/resource/pubmed/id/2465514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-4-6
pubmed:abstractText
Age-dependent changes in thermal nociceptive threshold, as determined by the hot plate test, occurred in rats treated neonatally with capsaicin. From 4 weeks of age, hot plate latency increased to a maximum at 8 weeks of age and then declined to control values by 16 weeks of age. Although substantially diminished by 10 days of age, calcitonin gene-related peptide (CGRP)-like immunoreactivity increased in laminae I and II between 8 and 16 weeks of age. In addition, a dense plexus of CGRP-like immunoreactive fibers appeared in laminae III and IV. Similar changes in substance P-like immunoreactivity were not observed. The parallel timecourse of these alterations suggests that CGRP is involved in nociceptive processing in the spinal cord.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-62
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance P after neonatal administration of capsaicin in the rat.
pubmed:affiliation
Department of Central Nervous System Diseases Research, G.D. Searle & Co., Skokie, IL 60077.
pubmed:publicationType
Journal Article