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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1988-6-2
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pubmed:abstractText |
Single channel recordings were obtained from inside-out patches of cultured human neuroblastoma cells (cell line SH-SY5Y) treated with a phorbol ester, 12-o-tetradecanoylphorbol-13-acetate (TPA) to induce differentiation. An outward current reversing near the calculated reversal potential for potassium was detected. This channel is transiently active at membrane potentials between -40 and -70 mV but with preceding hyperpolarizing pulses also at more positive potentials, up to +75 mV. The current seems to consist of two components; a slowly activating component at potentials negative to -40 mV and a fast component, more sensitive to 4-aminopyridine, seen at more positive potentials.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-104
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2452391-Cell Differentiation,
pubmed-meshheading:2452391-Humans,
pubmed-meshheading:2452391-Ion Channels,
pubmed-meshheading:2452391-Membrane Potentials,
pubmed-meshheading:2452391-Neuroblastoma,
pubmed-meshheading:2452391-Potassium,
pubmed-meshheading:2452391-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2452391-Tumor Cells, Cultured
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pubmed:year |
1988
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pubmed:articleTitle |
Single transient potassium channels in human neuroblastoma cells induced to differentiate in vitro.
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pubmed:affiliation |
Department of Biology, University of Turku, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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