pubmed-article:2447127 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:2447127 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
pubmed-article:2447127 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:2447127 | pubmed:dateCreated | 1988-2-9 | lld:pubmed |
pubmed-article:2447127 | pubmed:abstractText | IL-1 is a family of polypeptides which play a critical role in the inflammatory response. Characteristics of this response include an enhanced release of bone marrow neutrophils, activation of circulating and tissue-phase phagocytes, and enhanced production of neutrophils and monocytes. We have sought to understand the hematopoietic response to acute and chronic inflammatory states on a cellular and molecular level. Colony-stimulating factors (CSFs) are glycoproteins involved in the production and activation of neutrophils and monocytes in vitro and in vivo. We have found that quiescent dermal fibroblasts constitutively release granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), and macrophage CSF in culture, and that picomolar concentrations of the inflammatory mediator IL-1 stimulate by at least fivefold the transcription and release of GM-CSF and G-CSF. These findings establish the role of IL-1 in the hematopoietic response to inflammation through the stimulation of the production and release of GM-CSF and G-CSF. | lld:pubmed |
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pubmed-article:2447127 | pubmed:language | eng | lld:pubmed |
pubmed-article:2447127 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2447127 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:2447127 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2447127 | pubmed:month | Jan | lld:pubmed |
pubmed-article:2447127 | pubmed:issn | 0021-9738 | lld:pubmed |
pubmed-article:2447127 | pubmed:author | pubmed-author:AdamsonJ WJW | lld:pubmed |
pubmed-article:2447127 | pubmed:author | pubmed-author:LinNN | lld:pubmed |
pubmed-article:2447127 | pubmed:author | pubmed-author:KaushanskyKK | lld:pubmed |
pubmed-article:2447127 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2447127 | pubmed:volume | 81 | lld:pubmed |
pubmed-article:2447127 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2447127 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2447127 | pubmed:pagination | 92-7 | lld:pubmed |
pubmed-article:2447127 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:2447127 | pubmed:year | 1988 | lld:pubmed |
pubmed-article:2447127 | pubmed:articleTitle | Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. | lld:pubmed |
pubmed-article:2447127 | pubmed:affiliation | Division of Hematology, University of Washington, Seattle 98195. | lld:pubmed |
pubmed-article:2447127 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2447127 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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