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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1988-1-7
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pubmed:abstractText |
Action potentials in many types of excitable cells result from changes in permeability to Na ions. Although these permeability changes in nerve and muscle are mediated by voltage-gated Na channels that are functionally similar, we found that the Na-channel gene expressed in skeletal muscle is different from the genes coding for two Na channels (type I and type II) in brain. Despite the structural differences between muscle and brain Na-channel genes, a cDNA clone derived from rat brain hybridizes to skeletal muscle Na-channel mRNA of approximately 9.5 kilobases. We used this cDNA probe to measure changes in Na-channel mRNA levels in skeletal muscle during development and following denervation. By blot hybridization analysis of electrophoretically fractionated RNA, we found that Na-channel mRNA can be detected as early as embryonic day 17 and that mRNA levels increase 2-fold between birth and postnatal day 35. Denervation of adult muscle causes a further 2- to 3-fold increase in muscle Na-channel mRNA levels, suggesting that expression of Na-channel genes in fast-twitch muscle may be regulated by the state of innervation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-14946712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2425365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2425432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2429308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2432468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2433396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2442326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2580596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-2581954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-265521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-3079917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-3754035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-4032011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-4327036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-4514634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-4577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-5134176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6113244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6209577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6257898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6296148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6305931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6306551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6313211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2446331-6319405
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8721-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2446331-Age Factors,
pubmed-meshheading:2446331-Animals,
pubmed-meshheading:2446331-Gene Expression Regulation,
pubmed-meshheading:2446331-Ion Channels,
pubmed-meshheading:2446331-Muscle Denervation,
pubmed-meshheading:2446331-Muscle Development,
pubmed-meshheading:2446331-Muscles,
pubmed-meshheading:2446331-Nucleic Acid Hybridization,
pubmed-meshheading:2446331-RNA, Messenger,
pubmed-meshheading:2446331-Rats,
pubmed-meshheading:2446331-Sodium
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pubmed:year |
1987
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pubmed:articleTitle |
Modulation of sodium-channel mRNA levels in rat skeletal muscle.
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pubmed:affiliation |
Department of Medicine, Tufts-New England Medical Center, Boston, MA 02111.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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