| pubmed-article:2445667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2445667 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2445667 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:2445667 | lifeskim:mentions | umls-concept:C0040123 | lld:lifeskim |
| pubmed-article:2445667 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:2445667 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2445667 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2445667 | pubmed:dateCreated | 1987-12-23 | lld:pubmed |
| pubmed-article:2445667 | pubmed:abstractText | We have used a large panel of thyroglobulins (Tg) prepared from a wide range of mammalian species to study the Tg autoantigenic epitopes recognized by populations of monoclonal and polyclonal murine T and B cells. This approach showed the existence of at least six different epitopes; three recognized by T cells (in association with I-Ak on antigen-presenting cells) and three by B cells (monoclonal antibodies). The majority of serum and monoclonal autoantibodies were found to be highly specific for mouse Tg, with some cross-reactive binding to rat Tg. In contrast, T-cell lines/clones and hybridomas recognized cross-reactive epitopes on Tg that were highly conserved throughout most of the mammalian orders. Moreover, two hybrid clones, which showed similar patterns of cross-reactivity, differed in their responsiveness to tryptic digests of human Tg. Thus, autoreactive T and B cells recognize distinct areas of the Tg molecule. | lld:pubmed |
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| pubmed-article:2445667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2445667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2445667 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2445667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2445667 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2445667 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:2445667 | pubmed:author | pubmed-author:HendersonGG | lld:pubmed |
| pubmed-article:2445667 | pubmed:author | pubmed-author:ByfieldP GPG | lld:pubmed |
| pubmed-article:2445667 | pubmed:author | pubmed-author:ChampionB RBR | lld:pubmed |
| pubmed-article:2445667 | pubmed:author | pubmed-author:RaynerD CDC | lld:pubmed |
| pubmed-article:2445667 | pubmed:author | pubmed-author:Quartey-Papaf... | lld:pubmed |
| pubmed-article:2445667 | pubmed:author | pubmed-author:PageKK | lld:pubmed |
| pubmed-article:2445667 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2445667 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:2445667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2445667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2445667 | pubmed:pagination | 255-63 | lld:pubmed |
| pubmed-article:2445667 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2445667 | pubmed:meshHeading | pubmed-meshheading:2445667-... | lld:pubmed |
| pubmed-article:2445667 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2445667 | pubmed:articleTitle | Recognition of thyroglobulin autoantigenic epitopes by murine T and B cells. | lld:pubmed |
| pubmed-article:2445667 | pubmed:affiliation | Department of Immunology, Middlesex Hospital Medical School, U.K. | lld:pubmed |
| pubmed-article:2445667 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2445667 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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