Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-12-23
pubmed:abstractText
We have used a large panel of thyroglobulins (Tg) prepared from a wide range of mammalian species to study the Tg autoantigenic epitopes recognized by populations of monoclonal and polyclonal murine T and B cells. This approach showed the existence of at least six different epitopes; three recognized by T cells (in association with I-Ak on antigen-presenting cells) and three by B cells (monoclonal antibodies). The majority of serum and monoclonal autoantibodies were found to be highly specific for mouse Tg, with some cross-reactive binding to rat Tg. In contrast, T-cell lines/clones and hybridomas recognized cross-reactive epitopes on Tg that were highly conserved throughout most of the mammalian orders. Moreover, two hybrid clones, which showed similar patterns of cross-reactivity, differed in their responsiveness to tryptic digests of human Tg. Thus, autoreactive T and B cells recognize distinct areas of the Tg molecule.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-13546173, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-2412739, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-2421954, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-2422861, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-2434418, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-2579025, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-2978224, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-307029, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-323406, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-3758078, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-3838512, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-3855243, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-3874704, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-3967397, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-3971976, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-4993864, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6085753, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6160004, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6160739, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6183944, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6187336, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6237919, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6329669, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6600980, http://linkedlifedata.com/resource/pubmed/commentcorrection/2445667-6786978
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-63
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Recognition of thyroglobulin autoantigenic epitopes by murine T and B cells.
pubmed:affiliation
Department of Immunology, Middlesex Hospital Medical School, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't