Linked Life Data

2444442

Source:http://linkedlifedata.com/resource/pubmed/id/2444442

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-11-27
pubmed:abstractText
The effect of mebeverine, mebeverine-alcohol and veratric acid on voltage-operated ion channels and on sodium pump activity were studied. The amplitude and duration of the compound action potential evoked in the vagus nerve were decreased by mebeverine but not by the metabolites. The amplitude of the post-tetanic hyperpolarization was decreased by mebeverine while the time constant of decay, representing sodium-potassium pump activity, was not affected by the compounds tested. These results show that mebeverine exerts a local anaesthetic action by blocking voltage-operated sodium channels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
139
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The action of mebeverine and metabolites on mammalian non-myelinated nerve fibres.
pubmed:affiliation
Department of Pharmacology and Clinical Pharmacology, University of Groningen, The Netherlands.
pubmed:publicationType
Journal Article, In Vitro