Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-11-30
|
| pubmed:abstractText |
Peripheral blood leukocytes from ARC and AIDS patients were analyzed following phytohemagglutinin- and pokeweed mitogen-induced lymphocyte transformation by dual-color flow cytometry using monoclonal antibodies that identify developmental (HLA-DR) and functional (Leu8) subsets of T cells and monocytes. Significant decreases in both the suppressor regulating helper T subset (Leu3+ Leu8+) and the reciprocal inducer helper T subset (Leu3+ Leu8-) responsible for inducing differentiation of B cells were observed. Simultaneously, the percentages of the effector suppressor T cells and the precursor suppressor T cells were increased, both of which were required for generation of suppression of cell-mediated immunity. There was also a progressive selection of Ia+ cells bearing the Leu2 (Ts) markers and a concurrent reduction of the percentage of antigen-presenting monocytes and activated helper T cells. These results suggest that the functional deficiencies in AIDS may be caused by defects in T-cell activation as well as antigen presentation by monocytes. Isoprinosine induced an increase in both regulator Th (Leu3+ Leu8+) and inducer Th (Leu3+ Leu8+) subsets of helper T cells while potentiating the expression of Ia antigen on helper T cells and monocytes during mitogen-driven DNA synthesis. These events initiated a cascade of cellular interactions leading to partial restoration of cell-mediated immune responses. These interferences with the defective helper/suppressor regulatory pathways may have important therapeutic implications.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Inosine,
http://linkedlifedata.com/resource/pubmed/chemical/Inosine Pranobex
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0090-1229
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
166-76
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2444374-AIDS-Related Complex,
pubmed-meshheading:2444374-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2444374-Adjuvants, Immunologic,
pubmed-meshheading:2444374-Adult,
pubmed-meshheading:2444374-Antigen-Presenting Cells,
pubmed-meshheading:2444374-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2444374-B-Lymphocytes,
pubmed-meshheading:2444374-Histocompatibility Antigens Class II,
pubmed-meshheading:2444374-Humans,
pubmed-meshheading:2444374-Inosine,
pubmed-meshheading:2444374-Inosine Pranobex,
pubmed-meshheading:2444374-Leukocytes, Mononuclear,
pubmed-meshheading:2444374-Lymphocyte Activation,
pubmed-meshheading:2444374-Lymphocyte Cooperation,
pubmed-meshheading:2444374-Male,
pubmed-meshheading:2444374-Middle Aged,
pubmed-meshheading:2444374-T-Lymphocytes,
pubmed-meshheading:2444374-T-Lymphocytes, Helper-Inducer
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Isoprinosine-induced modulation of T-helper-cell subsets and antigen-presenting monocytes (Leu M3 + Ia +) resulted in improvement of T- and B-lymphocyte functions, in vitro in ARC and AIDS patients.
|
| pubmed:affiliation |
Department of Neoplastic Diseases, Mount Sinai School of Medicine, New York, New York 10029.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|