Linked Life Data

2434154

Source:http://linkedlifedata.com/resource/pubmed/id/2434154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1987-3-31
pubmed:abstractText
The ultrastructural features of normal human thymocytes were analyzed at various stages of immunologic differentiation as defined by a panel of OKT monoclonal antibodies visualized by colloidal gold labelled antimouse IgG. The study shows that first stage thymocytes (OKT10+, OKT9+) have a typical morphology not found in more mature stages and describes the critical ultrastructural change which they undergo in becoming second stage thymocytes (OKT10+, OKT6+, OKT8+, OKT4+). No change in thymocyte fine morphology has been found in the progression from second to third stage (OKT10+, OKT3+, OKT8+ or OKT10+, OKT3+, OKT4+). Cells with ultrastructural features intermediate between those of the first and second stage have been found to react with monoclonal antibodies characterizing the first and the second stage. Ultrastructural similarity and homogeneity found in OKT8+ and OKT4+ thymic subpopulations suggests the acquisition by T lymphocytes of morphologic structures correlate with immunologic features previously found in peripheral blood T cell subpopulations to be a post-thymic process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0753-3322
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Human thymocyte differentiation: an ultrastructural study using monoclonal antibodies and immunogold staining method.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't