Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1986-6-13
|
| pubmed:abstractText |
The clone TA10 is a T3+ T4+ T8- proliferative and cytolytic human T cell clone. This clone has been shown to be specific for the hemagglutinin of influenza A Texas virus and restricted by an HLA class II molecule associated with the DRw8-Dw8.1 phenotype. Here we show that TA10 and all of its subclones can also react with eight HLA-DRw8 negative, Epstein-Barr virus (EBV)-transformed cell lines or phytohemagglutinin blasts in the absence of influenza antigens. All of these cell lines are HLA-DR2/DR4 with a classic DR2 long haplotype. The only nonreactive HLA-DR2/DR4 cell line observed bears a DR2 short haplotype. Only heterozygous HLA-DR2/DR4 but not parental DR2 or DR4 EBV-transformed cell lines can be recognized by TA10, indicating that the cross-reacting determinant is a transcomplementation product between HLA-DR2 and HLA-DR4 haplotypes. DR-specific, but not DQ- or DP-specific monoclonal antibodies, inhibit in the proliferation assay and in the chromium release test both the DRw8-Dw8.1-restricted and the anti-DR2/DR4 reactions. These results show that HLA-DR-restricted, anti-viral human T cell clone can evidence cross-reactivity for allospecific class II molecules of the major histocompatibility complex, and human CTL can recognize transcomplementation products of class II HLA genes. In addition, the results suggest that a beta-chain coded for by an HLA-DR gene and associated with an alpha-chain coded for by a still unidentified but possibly HLA-DQ gene constitute this functional transcomplementation product.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Serological Subtypes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR8 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
136
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3961-7
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2422266-Antibodies, Monoclonal,
pubmed-meshheading:2422266-Binding, Competitive,
pubmed-meshheading:2422266-Cell Line,
pubmed-meshheading:2422266-Cell Transformation, Viral,
pubmed-meshheading:2422266-Clone Cells,
pubmed-meshheading:2422266-Cross Reactions,
pubmed-meshheading:2422266-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:2422266-Epitopes,
pubmed-meshheading:2422266-Genotype,
pubmed-meshheading:2422266-HLA-DR Antigens,
pubmed-meshheading:2422266-HLA-DR Serological Subtypes,
pubmed-meshheading:2422266-HLA-DR2 Antigen,
pubmed-meshheading:2422266-HLA-DR4 Antigen,
pubmed-meshheading:2422266-Herpesvirus 4, Human,
pubmed-meshheading:2422266-Histocompatibility Antigens Class II,
pubmed-meshheading:2422266-Humans,
pubmed-meshheading:2422266-Influenza A virus,
pubmed-meshheading:2422266-Lymphocyte Activation,
pubmed-meshheading:2422266-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
An influenza A virus-specific and HLA-DRw8-restricted T cell clone cross-reacting with a transcomplementation product of the HLA-DR2 and DR4 haplotypes.
|
| pubmed:publicationType |
Journal Article
|