Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-12-18
|
| pubmed:abstractText |
The extracellular patch clamp method was used to study the influence of pentobarbital (PB) on membrane channels induced by gamma-aminobutyric acid (GABA) in cultured mouse spinal neurons. PB (200 microM) increased the probability of finding GABA-sensitive channels in the open state; it also increased the average frequency at which GABA-induced single channel currents occur, without decreasing the number of data sweeps which showed no single channel activity. These results indicate that PB potentiates GABA responses by promoting burst-like openings of the GABA-sensitive channel.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
121-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2414696-Animals,
pubmed-meshheading:2414696-Cells, Cultured,
pubmed-meshheading:2414696-Drug Synergism,
pubmed-meshheading:2414696-Ion Channels,
pubmed-meshheading:2414696-Membrane Potentials,
pubmed-meshheading:2414696-Mice,
pubmed-meshheading:2414696-Pentobarbital,
pubmed-meshheading:2414696-Spinal Cord,
pubmed-meshheading:2414696-gamma-Aminobutyric Acid
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Pentobarbital promotes bursts of gamma-aminobutyric acid-activated single channel currents in cultured mouse central neurons.
|
| pubmed:publicationType |
Journal Article
|