Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-7-30
pubmed:abstractText
This study reports the partial characterization of nucleic acids present in gradient fractions enriched for large membrane vesicles from scrapie-infected and uninfected hamster brains. Labeling of phenol-extracted nucleic acids at the 3' or 5' ends revealed abundant amounts of low-molecular-weight RNA and little or no DNA. These nucleic acids survived nuclease treatment of membrane vesicles but were sensitive to RNase after phenol extraction. Analysis of 5'-end-labeled nucleic acids by one- and two-dimensional gel electrophoresis revealed an RNA of ca. 100 bases in preparations from scrapie-infected hamster brain that could not be detected in uninfected brain. The possibility that this apparently unique small RNA may result from tissue damage or abnormal RNA processing or may be a component of the infectious complex is discussed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-1167887, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-131866, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-3920349, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-3920350, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-4326373, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-4357505, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-4504350, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-4963878, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-4989433, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-5105163, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-5288383, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-6164981, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-6169437, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-6169438, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-6245238, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-6418385, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-6420511, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-6438273, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-7063400, http://linkedlifedata.com/resource/pubmed/commentcorrection/2409296-8342
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-32
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Characterization of nucleic acids in membrane vesicles from scrapie-infected hamster brain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't