|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024432,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0031308,
umls-concept:C0185117,
umls-concept:C0262950,
umls-concept:C0521009,
umls-concept:C1327413,
umls-concept:C1879547,
umls-concept:C2266975,
umls-concept:C2911684
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1990-4-6
|
|
pubmed:abstractText |
The lipopeptide N-palmitoyl-S-(2,3-bis(palmitoyloxy)-(2RS)-propyl)-(R)-cysteinyl-a lanyl-glycine (Pam3Cys-Ala-Gly), a synthetic analogue of the N-terminal part of bacterial lipoprotein, induces the secretion of interleukin (IL) 1, IL 6 and tumor necrosis factor (TNF)-alpha in bone marrow-derived macrophages that have been cultured in vitro for up to 20 days. IL 6 and TNF-alpha secretion increased from day 6 to day 20 whereas IL 1 secretion increased until day 13 and decreased on day 20. In contrast to the enhancement of cytokine production, phagocytosis of IgG-coated sheep erythrocytes and Ia expression were found to be diminished after treatment with lipopeptide for 24 h. Morphological studies revealed lipopeptide-induced changes of macrophage cultures. The data presented here show the potential of the lipopeptide as a strong activator of bone marrow-derived macrophages.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
63-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2407539-Animals,
pubmed-meshheading:2407539-Bacteria,
pubmed-meshheading:2407539-Bone Marrow Cells,
pubmed-meshheading:2407539-Cell Division,
pubmed-meshheading:2407539-Cell Line,
pubmed-meshheading:2407539-Cells, Cultured,
pubmed-meshheading:2407539-Colony-Stimulating Factors,
pubmed-meshheading:2407539-Cytotoxicity, Immunologic,
pubmed-meshheading:2407539-Histocompatibility Antigens Class II,
pubmed-meshheading:2407539-Interleukin-1,
pubmed-meshheading:2407539-Interleukin-6,
pubmed-meshheading:2407539-Lipoproteins,
pubmed-meshheading:2407539-Macrophage Activation,
pubmed-meshheading:2407539-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2407539-Macrophages,
pubmed-meshheading:2407539-Mice,
pubmed-meshheading:2407539-Mice, Inbred BALB C,
pubmed-meshheading:2407539-Phagocytosis,
pubmed-meshheading:2407539-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Activation of bone marrow-derived mouse macrophages by bacterial lipopeptide: cytokine production, phagocytosis and Ia expression.
|
|
pubmed:affiliation |
Institut für Immunbiologie, University of Freiburg, FRG.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
