|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1990-3-5
|
|
pubmed:abstractText |
A variety of antibodies to microtubule-associated protein (MAP) have been used to demonstrate that phosphorylation of a 350 kDa microtubule-associated protein is stimulated 2-3 fold by epidermal growth factor or serum in quiescent 3T3-L1 fibroblasts and by insulin in 3T3-L1 adipocytes. Phosphorylation occurs on serine residues, and is maximal by 15-20 min. The phosphoprotein has been identified as MAP1A by specific immunoprecipitation with a well-characterized monoclonal antibody.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
30
|
|
pubmed:volume |
166
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
827-32
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:2405857-Animals,
pubmed-meshheading:2405857-Epidermal Growth Factor,
pubmed-meshheading:2405857-Fibroblasts,
pubmed-meshheading:2405857-Insulin,
pubmed-meshheading:2405857-Mice,
pubmed-meshheading:2405857-Microtubule-Associated Proteins,
pubmed-meshheading:2405857-Molecular Weight,
pubmed-meshheading:2405857-Phosphoproteins,
pubmed-meshheading:2405857-Phosphoserine,
pubmed-meshheading:2405857-Precipitin Tests,
pubmed-meshheading:2405857-Protein Kinases
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Microtubule-associated protein 1A is the fibroblast HMW MAP undergoing mitogen-stimulated serine phosphorylation.
|
|
pubmed:affiliation |
Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
