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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-10-23
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pubmed:abstractText |
In a qualitative electron microscopy study we initially reported that exposure of rats to a standard clinical magnetic resonance imaging (MRI) procedure temporarily increased the blood-brain barrier (BBB) permeability to horseradish peroxidase. In this study, we quantitatively support our initial finding. Rats were injected intracardially with radio-labelled diethylenetriaminepentaacetic acid [( 153Gd]DTPA) in the middle of two sequential 23.2 min MRI exposures. Exposed rats (n = 21) showed significantly greater (29%, P = 0.006) retention of [153 Gd]DTPA than sham-exposed rats (n = 22) 1 h after the end of the last 23.2 min exposure. These findings suggest that magnetic fields may alter BBB permeability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
523
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2400915-Animals,
pubmed-meshheading:2400915-Blood-Brain Barrier,
pubmed-meshheading:2400915-Brain,
pubmed-meshheading:2400915-Gadolinium,
pubmed-meshheading:2400915-Gadolinium DTPA,
pubmed-meshheading:2400915-Horseradish Peroxidase,
pubmed-meshheading:2400915-Magnetic Resonance Imaging,
pubmed-meshheading:2400915-Male,
pubmed-meshheading:2400915-Organometallic Compounds,
pubmed-meshheading:2400915-Pentetic Acid,
pubmed-meshheading:2400915-Permeability,
pubmed-meshheading:2400915-Radioisotopes,
pubmed-meshheading:2400915-Rats,
pubmed-meshheading:2400915-Rats, Inbred Strains
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pubmed:year |
1990
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pubmed:articleTitle |
Magnetic resonance imaging increases the blood-brain barrier permeability to 153-gadolinium diethylenetriaminepentaacetic acid in rats.
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pubmed:affiliation |
Department of Nuclear Medicine, St. Joseph's Health Centre, London, Ont., Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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