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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
|
| pubmed:dateCreated |
1990-10-12
|
| pubmed:abstractText |
Eosinophilia-myalgia syndrome, a newly recognized disorder that occurred in epidemic proportions during 1989, is associated with ingestion of manufactured tryptophan. A case is defined by debilitating myalgias and absolute eosinophilia greater than or equal to 1.0 x 10(9) cells/L. As of July 10, 1990, a total of 1531 cases had been reported nationwide, including 27 deaths. The highest rates of reported illness are concentrated in the western states, 68% are non-Hispanic white women aged 35 years and older, and data on associated clinical findings suggest a multisystemic disorder. The most frequent features include arthralgia (73%), rash (60%), cough or dyspnea (59%), peripheral edema (59%), elevated aldolase level (46%), and elevations in the results of liver function tests (43%). Neuropathy or neuritis, resulting in paralysis and death in some patients, was seen in 27%, and chest roentgenogram abnormalities were noted in 21% of those tested. Ninety-one percent reported onset of symptoms during or after May 1989, and 97% reported having taken tryptophan before the onset of symptoms. Since the recall of over-the-counter preparations of tryptophan in November 1989, the number of new cases of this potentially fatal disorder has fallen dramatically.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0098-7484
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
264
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1698-703
|
| pubmed:dateRevised |
2006-11-7
|
| pubmed:meshHeading |
pubmed-meshheading:2398610-Adolescent,
pubmed-meshheading:2398610-Adult,
pubmed-meshheading:2398610-Aged,
pubmed-meshheading:2398610-Aged, 80 and over,
pubmed-meshheading:2398610-Child,
pubmed-meshheading:2398610-Child, Preschool,
pubmed-meshheading:2398610-Disease Outbreaks,
pubmed-meshheading:2398610-Eosinophilia,
pubmed-meshheading:2398610-Female,
pubmed-meshheading:2398610-Humans,
pubmed-meshheading:2398610-Male,
pubmed-meshheading:2398610-Middle Aged,
pubmed-meshheading:2398610-Muscles,
pubmed-meshheading:2398610-Pain,
pubmed-meshheading:2398610-Population Surveillance,
pubmed-meshheading:2398610-Seasons,
pubmed-meshheading:2398610-Syndrome,
pubmed-meshheading:2398610-Tryptophan,
pubmed-meshheading:2398610-United States
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Eosinophilia-myalgia syndrome. Results of national surveillance.
|
| pubmed:affiliation |
Division of Environmental Hazards and Health Effects, Centers for Disease Control, Atlanta, Ga.
|
| pubmed:publicationType |
Journal Article
|