Linked Life Data

2394206

Source:http://linkedlifedata.com/resource/pubmed/id/2394206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-10-10
pubmed:abstractText
Previous studies on the platelet agonist activity of cotton bract condensed tannin have used tannins with apparent molecular weights greater than 10,000 Da as measured by dialysis and/or ultrafiltration. However, because tannins in cotton dust are heterogeneous in terms of molecular weight, it was important to determine if platelet agonist activity was related to polymer length. To accomplish this, aqueous extracts of cotton dust were fractionated by a series of graded Amicon ultrafiltrations and the resulting fractions were examined for tannin content and platelet agonist activity. All tannins with apparent molecular weight greater than 1000 Da were equally potent platelet agonists while those less than 1000 Da had no measurable platelet agonist activity. This polymer length dependence for activity was supported by the observation that two procyanidin dimers had only minimal platelet agonist activity. In addition, methylation of the tannin hydroxyl groups resulted in the loss of platelet agonist activity. Thus, the platelet agonist activity of tannin requires a minimum polymer length and the presence of free hydroxyl groups.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-209
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Structural determinants of the platelet agonist activity of cotton bract condensed tannin.
pubmed:affiliation
Thoracic Diseases Research Unit, Mayo Clinic/Foundation, Rochester, Minnesota 55905.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't