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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1990-9-27
|
| pubmed:abstractText |
The authors administered high-dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP-16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long-term, disease-free survival rate was 14%. Comparison of results with other treatments can be difficult because of patient selection biases. The concept of inversion (achievement of a longer remission with salvage therapy than with prior treatments) is proposed to compare treatment results. Three patients remain in complete remission beyond 4 years, with inversions. More intensive cytoreductive regimens will be needed to improve results.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0008-543X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
619-26
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2386890-Adult,
pubmed-meshheading:2386890-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2386890-Bone Marrow Transplantation,
pubmed-meshheading:2386890-Carmustine,
pubmed-meshheading:2386890-Combined Modality Therapy,
pubmed-meshheading:2386890-Cyclophosphamide,
pubmed-meshheading:2386890-Etoposide,
pubmed-meshheading:2386890-Female,
pubmed-meshheading:2386890-Granulocytes,
pubmed-meshheading:2386890-Humans,
pubmed-meshheading:2386890-Leukemia, Myeloid, Acute,
pubmed-meshheading:2386890-Leukocyte Count,
pubmed-meshheading:2386890-Male,
pubmed-meshheading:2386890-Middle Aged,
pubmed-meshheading:2386890-Platelet Count,
pubmed-meshheading:2386890-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:2386890-Remission Induction,
pubmed-meshheading:2386890-Survival Rate
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
High-dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission.
|
| pubmed:affiliation |
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-3330.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|