|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1990-9-13
|
|
pubmed:abstractText |
Eleven lipophilic derivatives of the title biogenic amines and 28 structurally related triamines and tetramines have been synthesized. Twenty-three of them inhibited the platelet aggregation induced by collagen at an IC50 between 8 mumol/L and 30 mumol/L. Five compounds prolonged the one stage thromboplastin time (Quick) by 7s or more at 100 mumol/L. The antiplatelet and anticoagulant effect do not run parallel. The relationship between the effects observed and the chemical structure of the oligoamines has been elucidated.
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|
pubmed:language |
ger
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0365-6233
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
323
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
287-94
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
[Antiaggregatory and anticoagulant effects of oligoamines. 12. Alkyl- and arylalkyl- derivatives of putrescine, spermidine and spermine].
|
|
pubmed:affiliation |
Institut für Pharmazie, Freien Universität Berlin.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
|
