Linked Life Data

2382268

Source:http://linkedlifedata.com/resource/pubmed/id/2382268

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-9-13
pubmed:abstractText
The decomposition of H2O2 by catalase (CAT) was measured in a cell-free in vitro system in the presence of 0-24 mM Ni(II) or Mg(II) as well as in red blood cells (RBCs), and in post-mitochondrial fractions of liver and kidney of rats injected i.p. with 95 mumol/kg of nickel acetate. In vitro, immediately after addition of Ni(II), the inhibition of the catalytic activity of CAT (at 25 degrees C and pH 7.2) was directly proportional to Ni(II) concentration while Mg(II) had no effect. Following in vivo treatment, activity of CAT in the RBCs was decreased by 12% at 16 h, but had returned to control level by 48 h post injection. Hepatic CAT activity remained unchanged during the first 24 h after the injection but subsequently decreased by 25% at 48 h. Renal CAT first increased by 17% above the control levels at 16 h, returned to the control level at 24 h, and finally decreased by 27% at 48 h post injection. These changes neither concurred with the corresponding tissue concentrations of Ni(II) nor resembled the concentration/effect relationships observed in vitro. Thus, the mechanism by which Ni(II) inhibits CAT activity in vivo is more complex than that in vitro and cannot be solely related to direct Ni(II)-CAT interaction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of nickel on catalase activity in vitro and in vivo.
pubmed:affiliation
Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21701.
pubmed:publicationType
Journal Article, In Vitro