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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1990-9-6
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pubmed:abstractText |
The homopyrimidine-homopurine sequence d(CT/GA)22 undergoes, in the presence of zinc ions, transition to an altered DNA conformation (*H-DNA) which is neither H-DNA nor B-DNA. *H-DNA is characterized by a peculiar chemical reactivity pattern in which most of the polypyrimidine strand is hyperreactive to osmium tetroxide and the central part of the polypurine strand is sensitive to diethylpyrocarbonate. Formation of *H-DNA is specific of metal-ion. *H-DNA is detected in the presence of Zn++, Cd++ and Mn++. The efficiency on promoting the transition is in the order of Zn++ greater than Cd++ much greater than Mn++. Formation of *H-DNA is also specific of nucleotide sequence. From all the different homopolymeric sequences tested only the d(CT/GA)22 sequence showed the zinc-induced transition to *H-DNA. These results suggest that stabilization of *H-DNA involves the formation of a specific complex between the metal-ion and the nucleotide sequence. The biological relevance of these results is discussed in view of the important role that zinc ions play on many nucleic acids processes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2377452-2303044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2377452-2411549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2377452-2499084,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4067-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2377452-Base Sequence,
pubmed-meshheading:2377452-Cadmium,
pubmed-meshheading:2377452-Calcium,
pubmed-meshheading:2377452-Cobalt,
pubmed-meshheading:2377452-Copper,
pubmed-meshheading:2377452-DNA,
pubmed-meshheading:2377452-Magnesium,
pubmed-meshheading:2377452-Manganese,
pubmed-meshheading:2377452-Molecular Sequence Data,
pubmed-meshheading:2377452-Nickel,
pubmed-meshheading:2377452-Nucleic Acid Conformation,
pubmed-meshheading:2377452-Zinc
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pubmed:year |
1990
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pubmed:articleTitle |
DNA-sequence and metal-ion specificity of the formation of *H-DNA.
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pubmed:affiliation |
Grupo de Química Macromolecular, Centro de Investigación y Desarrollo CSIC, ETSEIB, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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