Linked Life Data

2366476

Source:http://linkedlifedata.com/resource/pubmed/id/2366476

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-8-16
pubmed:abstractText
To the authors' knowledge, adenosine has not yet been shown to play any functional role in the mammalian retina, although it has been shown that it induces neuromodulation and an antiepileptogenic action of the purine in the brain. In order to test effects on retinal function, adenosine was administered intraarterially, in micromolar concentrations, to dark-adapted, isolated, perfused cat eyes. Light-evoked (rod-matched) electrical signals were recorded. Adenosine induced a marked increase in the amplitude of the ERG b-wave, a dose-dependent depression of the optic nerve response, and an increase in the flow rate of the perfusate - indicative of vasodilation. These data, together with autoradiographically demonstrated uptake of adenosine (2) are the first evidence that adenosine plays a functional role at several sites in the cat retina.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0023-2165
pubmed:author
pubmed:issnType
Print
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-71
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Effects of adenosine on the electrophysiology of the retina].
pubmed:affiliation
Neurophysiologie-Labor, Universitäts-Augenklinik Zürich.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't