Linked Life Data

2364990

Source:http://linkedlifedata.com/resource/pubmed/id/2364990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-8-13
pubmed:abstractText
The quantitative [14C]iodoantipyrine autoradiographic method was applied to study the effects of acute administration of caffeine and L-phenylisopropyladenosine (LPIA) separately or in combination on local cerebral blood flow in the rat. After the injection of caffeine, cerebral blood flow rates were decreased in 13 out of the 61 structures studied, mainly in motor and auditory areas. The administration of LPIA induced a general decrease in local cerebral blood flow, which was significant in only 4 regions. The combined administration of caffeine and LPIA induced decreases in blood flow rates in 17 brain areas, motor, limbic and hypothalamic structures and increases in 3 limbic regions. The results confirm previous data on the effect of caffeine on cerebral circulation. The consequences of LPIA administration on blood flow may originate partly from peripheral effects and may also be the reflection of the reduction in the energy demand of the brain. Finally, LPIA also seems to be able to modulate caffeine effects on local cerebral blood flow when injected simultaneously with caffeine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
179
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of caffeine, L-phenylisopropyladenosine and their combination on local cerebral blood flow in the rat.
pubmed:affiliation
INSERM U. 272, Nancy, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't