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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1990-8-15
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pubmed:abstractText |
Using hybrid mice BDF1 doxorubicin (Dx) accumulation has been determined in leukemia P388 cells (P388/0), P388 cells with induced resistance to Dx (P388/Dx) and P388 cells with induced resistance to the finoptin (Fp) + Dx combination (P388/Fp + Dx). It has been shown that Fp doesn't affect Dx accumulation in or elimination from leukemia cells P388/0 or P388/Fp + Dx. The resistance of P388/Fp + Dx cells to the Fp + Dx combination develops during 6 passages. It can be concluded that Fp application doesn't abolish the problem of tumor cells' resistance to cytostatics.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0365-9615
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
290-2
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pubmed:dateRevised |
2008-10-8
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pubmed:meshHeading |
pubmed-meshheading:2364157-Animals,
pubmed-meshheading:2364157-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2364157-Doxorubicin,
pubmed-meshheading:2364157-Drug Interactions,
pubmed-meshheading:2364157-Drug Resistance,
pubmed-meshheading:2364157-Drug Screening Assays, Antitumor,
pubmed-meshheading:2364157-Leukemia, Experimental,
pubmed-meshheading:2364157-Leukemia P388,
pubmed-meshheading:2364157-Male,
pubmed-meshheading:2364157-Mice,
pubmed-meshheading:2364157-Mice, Inbred C57BL,
pubmed-meshheading:2364157-Mice, Inbred DBA,
pubmed-meshheading:2364157-Time Factors,
pubmed-meshheading:2364157-Verapamil
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pubmed:year |
1990
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pubmed:articleTitle |
[The effect of finoptin on doxorubicin accumulation in leukemia P-388 cells with induced resistance to the combination of finoptin and doxorubicin].
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|