Linked Life Data

2354038

Source:http://linkedlifedata.com/resource/pubmed/id/2354038

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-7-24
pubmed:abstractText
To determine whether tolerance to morphine-induced anorexia requires access to milk while intoxicated, rats were given chronic injections of morphine (10 or 20 mg/kg) either before (before subgroups) or after (after subgroups) access to milk on alternate days. There were marked individual differences in initial sensitivity to the drug. After chronic treatment, there was little difference in the level of tolerance in subjects given morphine either before or after access to milk. On the intervening nondrug days, rats in the before subgroups consistently drank less milk than the other subgroups. This effect was not the result of withdrawal distress. Substitution of saline for morphine (20 mg/kg) on a scheduled drug day resulted in enhanced milk intakes in both the before and after subgroups. The results suggest that tolerance to morphine anorexia does not involve instrumental learning.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0735-7044
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Tolerance to morphine "anorexia" is not contingent on experience with food while in the drugged state.
pubmed:affiliation
Institute for the Study of Alcohol and Drug Dependence, Florida Atlantic University, Boca Raton 33431-0991.
pubmed:publicationType
Journal Article