Linked Life Data

2353562

Source:http://linkedlifedata.com/resource/pubmed/id/2353562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-7-13
pubmed:abstractText
Adjuvant chemotherapy is a well accepted concept in the treatment of breast cancer and has resulted in most clinical studies in a significant prolongation of the disease-free interval in certain subgroups of patients. However, very little is known about the late effects of adjuvant chemotherapy and its influence upon the function of a series of physiologic mechanisms. In the present paper, a review of our studies on the influence of adjuvant chemotherapy consisting of cyclophosphamide, methotrexate and fluoruracil (CMF) upon the function of B, T and natural killer (NK) cells is given. It is shown that CMF adversely influenced primary antibody production following vaccination for a prolonged period of time after the termination of CMF treatment. In investigating T cell function, it was found that the administration of CMF led also to a similarly prolonged impairment of phytohemagglutinin (PHA-)stimulated soluble interleukin 2 receptor (sIL-2R) production and to a decrease in the proliferation of peripheral blood mononuclear cells following mitogenic stimulation with PHA. Finally, NK cell activity was found to be decreased for such a prolonged period of time after the termination of CMF treatment, too. We thus conclude that the administration of CMF in the adjuvant setting leads to a pronounced and prolonged impairment of certain immune mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0303-8173
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-4
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of adjuvant chemotherapy on specific and non-specific immune mechanisms.
pubmed:affiliation
IInd Department of Medicine, University Hospital, Austria.
pubmed:publicationType
Journal Article