Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1990-7-11
|
| pubmed:abstractText |
We sought to determine the longitudinal distribution of pulmonary vascular resistance (PVR) in acute lactic acidosis utilizing pulmonary artery and vein balloon occlusion techniques (Holloway et al. J. Appl. Physiol. 54: 840-851, 1983). In anesthetized dogs, both a systemic vein (I-V) infusion and systemic artery (I-A) infusion of L-lactic acid were studied to control for potential effects of factors other than pH on PVR. During progressive I-A infusion (n = 9) to a pH of 6.94 +/- 0.06 there was no significant change in PVR or its distribution. In contrast, I-V infusion (n = 9) to a pH of 7.08 +/- 0.09 increased median PVR from 3.6 to 21.7 mmHg.1(-1).min (P less than 0.001), due to an increase in middle segment resistance (0.0-15.4 mmHg.1(-1).min, P less than 0.02). Examination by light and electron microscopy demonstrated pulmonary capillary obstruction with hemolyzed erythrocyte (RBC) membranes with I-V infusion, but representative I-A animals did not demonstrate these findings. Conceivably, the systemic vascular bed filtered the fragmented RBC membranes in the I-A model, but this microvascular obstruction with altered RBCs and RBC fragments caused the pulmonary hypertension observed in the I-V infusion. We conclude that lactic acidosis does not increase pulmonary vascular tone in dogs, a finding compatible with most previous studies in which observed increases in PVR may be attributed to other effects from I-V acid infusion on circulating blood elements.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
68
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1328-36
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2347775-Acidosis, Lactic,
pubmed-meshheading:2347775-Animals,
pubmed-meshheading:2347775-Blood Pressure,
pubmed-meshheading:2347775-Capillaries,
pubmed-meshheading:2347775-Cardiac Output,
pubmed-meshheading:2347775-Dogs,
pubmed-meshheading:2347775-Erythrocyte Membrane,
pubmed-meshheading:2347775-Erythrocytes,
pubmed-meshheading:2347775-Hydrogen-Ion Concentration,
pubmed-meshheading:2347775-Infusions, Intra-Arterial,
pubmed-meshheading:2347775-Infusions, Intravenous,
pubmed-meshheading:2347775-Lactates,
pubmed-meshheading:2347775-Lactic Acid,
pubmed-meshheading:2347775-Lung,
pubmed-meshheading:2347775-Male,
pubmed-meshheading:2347775-Microscopy, Electron,
pubmed-meshheading:2347775-Pulmonary Artery,
pubmed-meshheading:2347775-Pulmonary Veins,
pubmed-meshheading:2347775-Vascular Resistance
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Distribution of pulmonary vascular resistance during lactic acid infusion in dogs.
|
| pubmed:affiliation |
Section of Pulmonary and Critical Care Medicine, University of Chicago, Illinois.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|