|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001041,
umls-concept:C0001443,
umls-concept:C0030685,
umls-concept:C0034650,
umls-concept:C0076760,
umls-concept:C0391871,
umls-concept:C0501384,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1704675,
umls-concept:C1963578
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1990-6-27
|
|
pubmed:abstractText |
The putative intracellular calcium (Ca) antagonist TMB-8 was shown to reduce postjunctional sensitivity and quantal acetylcholine (ACh) release at low micromolar concentrations. At 10-fold higher concentrations, TMB-8 also blocked caffeine-induced Ca release (as monitored electrophysiologically by changes in ACh release) but did not impair the ability of adenosine to inhibit quantal ACh release. This last result implies that TMB-8 and adenosine exert their inhibitory actions at different steps in the depolarization-secretion coupling sequence.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0014-2999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
178
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
259-66
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
The effects of TMB-8 on acetylcholine release from frog motor nerve: interactions with adenosine.
|
|
pubmed:affiliation |
Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
