Linked Life Data

2323029

Source:http://linkedlifedata.com/resource/pubmed/id/2323029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-5-24
pubmed:abstractText
Previous work showed that adhesive contacts made by growth cone filopodia involve extracellular filaments that can be labeled with an antiserum to adherons (adhesion-promoting complexes in conditioned medium). Here, adheron antigens were found to be differentially expressed by particular cell types and synaptic layers during chick retina development, and this differential expression at the cellular level was retained in culture. When applied to living cells, adheron antibodies characteristically patched at filopodial junctions. Monospecific antibodies to purpurin and a heparan sulphate proteoglycan (HSPG), two components of adherons, labeled a subpopulation of junctions. Most interestingly, anti-purpurin and anti-HSPG bound only to one end of adhesive filaments. Such localization to discrete microdomains provides support for a heterotypic adhesive mechanism in junction formation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-16
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Biochemical differentiation of nascent neurite junctions: unilateral localization of adheron components.
pubmed:affiliation
Department of Neurobiology and Physiology, Northwestern University Institute for Neuroscience, Northwestern University, Evanston, IL 60208.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.