Linked Life Data

2315958

Source:http://linkedlifedata.com/resource/pubmed/id/2315958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-4-26
pubmed:abstractText
It has been reported previously that BALB/c mice, treated in utero with chlordane, showed increased survival to influenza A/PR/8/34 [H1N1] (influenza) virus as young adults. To determine the possible role of cell-mediated immunity (CMI) on this effect, cytotoxic T-lymphocyte (CTL) and natural killer (NK) cell activities were assessed on chlordane-exposed offspring at 100 and 200 days post partum. The CTL response of these offspring showed no significant change from that obtained from their sex- and age-matched control counterparts exposed prenatally to the vehicle. NK responses of chlordane-exposed female offspring were significantly higher at 100 days of age but not at 200 days of age. Although male offspring that were exposed to chlordane prenatally showed no difference in NK cell activity at 100 days of age, NK cell activity was significantly less in chlordane-treated animals than controls at 200 days of age. Thus, prenatal treatment of mice with chlordane had varying effects on the NK cell activity of adult offspring, depending on the sex and age of the animal. It is concluded that the previously reported increase in survival to influenza is due to a resolution of the infection by normal CTL and NK cell activities coupled with a decrease in delayed-type hypersensitivity (DTH)-mediated pathology.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cytotoxic T-lymphocyte and NK responses in mice treated prenatally with chlordane.
pubmed:affiliation
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.