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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-3-16
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pubmed:abstractText |
We introduced an IL-6 cDNA expression vector into a murine B cell line, the growth of which definitely required the presence of exogenous IL-6. The transfected cells secreted substantial amounts of IL-6, to which they themselves responded by proliferating without further requirement of exogenous IL-6. The proliferation was a direct function of cell density and was inhibitable by antibodies to IL-6, indicating the autocrine nature of the growth. The IL-6 cDNA-transfected cells displayed greatly enhanced tumorigenicity when inoculated into syngeneic and nude mice. Our data suggest that an IL-6 autocrine self stimulation confers on B cells a selective growth advantage and results in the induction of progression of the malignant state of B cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-113458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-14488296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-211512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2419912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2444978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2521241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2783861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2829354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2874849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2948184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2965020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-2965738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3076767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3127525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3257241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3258006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3261180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3263188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3289574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3488815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3490495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3491991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3493321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3493322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3496392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3497029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3499611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3501121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3726549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3758081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3883191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-3931081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-6234223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-6246525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-6304883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-6952201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-6975346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2303779-7412807
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-400
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2303779-Animals,
pubmed-meshheading:2303779-Antibodies,
pubmed-meshheading:2303779-B-Lymphocytes,
pubmed-meshheading:2303779-Cell Division,
pubmed-meshheading:2303779-DNA,
pubmed-meshheading:2303779-Humans,
pubmed-meshheading:2303779-Interleukin-6,
pubmed-meshheading:2303779-Mice,
pubmed-meshheading:2303779-Mice, Inbred BALB C,
pubmed-meshheading:2303779-Plasmids,
pubmed-meshheading:2303779-Recombinant Proteins,
pubmed-meshheading:2303779-Transfection
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pubmed:year |
1990
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pubmed:articleTitle |
Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA.
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pubmed:affiliation |
Department of Immunology, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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