Linked Life Data

2302575

Source:http://linkedlifedata.com/resource/pubmed/id/2302575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-3-19
pubmed:abstractText
Effects of FKS-508 (AF102B; cis-2-methylspiro (1,3-oxathiolane-5,3')-quinuclidine), a novel M1-selective agonist, on central muscarinic responses in mice were examined in comparison with oxotremorine. FKS-508 was slightly less potent (6 times) in reversal of scopolamine-induced amnesia (passive avoidance failure), but far less potent (260 and 55 times) in producing hypothermia and tremor than oxotremorine. These results show that the selective M1 agonist FKS-508 differentiates highly between the central muscarinic effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
507
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
172-5
pubmed:dateRevised
2004-12-21
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.
pubmed:affiliation
Research Institute of Life Science, Snow Brand Milk Products Co. Ltd., Tochigi, Japan.
pubmed:publicationType
Journal Article