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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
6
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|
pubmed:dateCreated |
1991-3-29
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|
pubmed:abstractText |
Thirty patients aged 26 to 70 years with a history of chronic osteoarthritis of at least eight years were randomly assigned to receive 20 mg daily of beta-cyclodextrin-piroxicam (beta-CDP) or tenoxicam for eight weeks. Both drugs effectively reduced pain, inflammation, and functional limitations of the affected joints. Endoscopy revealed minor posttreatment hemorrhagic lesions and erosions; these tended to be less severe in the group treated with beta-CDP than with tenoxicam. Slight to moderate gastrointestinal symptoms were reported by one patient treated with beta-CDP and three patients treated with tenoxicam; the symptoms were poorly correlated with endoscopic findings. It is concluded that both drugs are safe and effective in the control of symptoms in patients with chronic osteoarthritis.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0149-2918
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
547-55
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2289222-Adult,
pubmed-meshheading:2289222-Aged,
pubmed-meshheading:2289222-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:2289222-Chronic Disease,
pubmed-meshheading:2289222-Cyclodextrins,
pubmed-meshheading:2289222-Drug Therapy, Combination,
pubmed-meshheading:2289222-Duodenoscopy,
pubmed-meshheading:2289222-Duodenum,
pubmed-meshheading:2289222-Female,
pubmed-meshheading:2289222-Gastric Mucosa,
pubmed-meshheading:2289222-Gastroscopy,
pubmed-meshheading:2289222-Humans,
pubmed-meshheading:2289222-Intestinal Mucosa,
pubmed-meshheading:2289222-Male,
pubmed-meshheading:2289222-Middle Aged,
pubmed-meshheading:2289222-Osteoarthritis,
pubmed-meshheading:2289222-Piroxicam,
pubmed-meshheading:2289222-beta-Cyclodextrins
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|
pubmed:articleTitle |
Efficacy and gastrointestinal tolerability of beta-cyclodextrin-piroxicam and tenoxicam in the treatment of chronic osteoarthritis.
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pubmed:affiliation |
Digestive Endoscopic Service, I.O.M.I. Institute Messina, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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