Linked Life Data

2272351

Source:http://linkedlifedata.com/resource/pubmed/id/2272351

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-2-28
pubmed:abstractText
A 50-min treatment of longitudinal smooth muscle of guinea-pig ileum with propylbenzilylcholine mustard (PrBCM, 3 x 10(-6) M) irreversibly inhibited the responses elicited by carbachol. However, a 90-min treatment with PrBCM had no further significant inhibitory effect on the responses to carbachol, suggesting that there are two subtypes of muscarinic cholinoceptors, PrBCM-sensitive and PrBCM-insensitive receptors. Carbachol caused a rapid increase in cytosolic Ca2+ concentrations ([Ca2+]i), which was followed by a rapid increase in muscle tension in both untreated and PrBCM-treated preparations. There was a positive correlation between [Ca2+]i (R340/380) and tension developed in response to carbachol. A regression line for the two responses was obtained in each preparation. The slope of the line obtained with untreated preparations was steeper than that obtained with PrBCM-treated preparations. These data suggest that, upon activation, PrBCM-sensitive receptors use cytosolic Ca2+ more effectively than PrBCM-insensitive receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
187
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Activation of propylbenzilylcholine mustard-sensitive muscarinic cholinoceptors more effectively utilizes cytosolic Ca2+ for contraction in guinea-pig intestinal smooth muscle.
pubmed:affiliation
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't