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pubmed-article:2267567pubmed:abstractTextThe effect of noradrenaline and adrenaline on isolated smooth muscle from the reticular groove of calves was studied. Both catecholamines caused a concentration-dependent (1.1.10(-6) mol/l) contraction of the transversal muscle strips from the floor of the reticular groove. This excitatory effect was antagonized by prazosin (10(-7)) mol/l), and by high concentrations of yohimbine (10(-6) mol/l) and atropine (10(-5)) mol/l). Tetrodotoxin (3.10(-6) mol/l), an inhibitor of nerve conduction, did not change the contraction induced by catecholamines (55.10(-6)) mol/l). Catecholamines did not produce a contraction of the longitudinal muscle from the lips of the reticular groove. The beta-adrenergic agonist isoprenaline (55.10(-6) mol/l) even elicited a reduction of acetylcholine (55.10(-6)) mol/l) induced contraction of both the transversal and the longitudinal muscle from the reticular groove. The relaxing effect of isoprenaline was antagonized by propranolol (55.10(-6)) mol/l). According to these results the excitatory effect of catecholamines on the smooth muscle cells occurs through alpha-adrenergic receptors, whereas the relaxing effect is mediated by beta-adrenergic receptors of the muscle cell. The excitatory effect of catecholamines on the transversal muscle appears to be predominant. Atropine appears to be an unspecific blocking agent of alpha-adrenergic receptors.lld:pubmed
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pubmed-article:2267567pubmed:authorpubmed-author:MartiJJlld:pubmed
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pubmed-article:2267567pubmed:pagination491-6lld:pubmed
pubmed-article:2267567pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2267567pubmed:articleTitle[Effect of catecholamines on the smooth muscles of the esophageal groove of calves].lld:pubmed
pubmed-article:2267567pubmed:affiliationInstitut für Veterinärphysiologie, Universität Zürich.lld:pubmed
pubmed-article:2267567pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2267567pubmed:publicationTypeEnglish Abstractlld:pubmed