Linked Life Data

2267138

Source:http://linkedlifedata.com/resource/pubmed/id/2267138

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1991-2-14
pubmed:abstractText
The retinoblastoma (Rb) gene is a recessive oncogene or tumor-suppressor gene whose inactivation leads to the development of tumors. Recently, evidence pointing to a role for the Rb gene in the differentiation of certain human cell types has been presented. We have studied three mouse cell lineages to determine whether there is a correlation between Rb gene expression and differentiation. We find that induction of mouse erythroleukemia cell differentiation with either dimethylsulfoxide (DMSO) or hexamethylene bisacetamide (HMBA) leads to increased expression of Rb mRNA. Increased expression of Rb mRNA was also found in S2 myoblasts induced by mitogen depletion to become differentiated myotubes. In the B-cell lineage, Rb expression is low in pre-B and B cell lines but high in plasmacytomas, which represent late stages of B cell differentiation. Thus, in all three lineages (erythroid, muscle, and B-cell) late stages of differentiation are associated with increased amounts of Rb mRNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1731-3
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Increased retinoblastoma gene expression is associated with late stages of differentiation in many different cell types.
pubmed:affiliation
Department of Biology, Princeton University, New Jersey 08544-1014.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't