Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-2-1
pubmed:databankReference
pubmed:abstractText
Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein, gp130, which associates with IL-6 receptor (IL-6-R). A cDNA encoding human gp130 has been cloned, revealing that it consists of 918 amino acids with a single transmembrane domain. The extracellular region comprises six units of a fibronectin type III module, and part of this region of approximately 200 amino acids has features typical of a cytokine receptor family. A cDNA-expressed gp130 showed no binding property to IL-6 or several other cytokines. Although a transfectant with an IL-6-R cDNA expressed mainly low affinity IL-6 binding sites, an increase in high affinity binding sites was observed after cotransfection with a gp130 cDNA. This confirmed that a gp130 is involved in the formation of high affinity IL-6 binding sites. A cloned gp130 could associate with a complex of IL-6 and soluble IL-6-R and transduce the growth signal when expressed in a murine IL-3-dependent cell line.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1149-57
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2261637-Amino Acid Sequence, pubmed-meshheading:2261637-Animals, pubmed-meshheading:2261637-Antibodies, Monoclonal, pubmed-meshheading:2261637-Antigens, CD, pubmed-meshheading:2261637-Base Sequence, pubmed-meshheading:2261637-Cell Division, pubmed-meshheading:2261637-Cell Line, pubmed-meshheading:2261637-Cloning, Molecular, pubmed-meshheading:2261637-Cytokine Receptor gp130, pubmed-meshheading:2261637-Female, pubmed-meshheading:2261637-Gene Expression, pubmed-meshheading:2261637-Gene Library, pubmed-meshheading:2261637-Humans, pubmed-meshheading:2261637-Interleukin-6, pubmed-meshheading:2261637-Membrane Glycoproteins, pubmed-meshheading:2261637-Molecular Sequence Data, pubmed-meshheading:2261637-Placenta, pubmed-meshheading:2261637-Pregnancy, pubmed-meshheading:2261637-Receptors, Immunologic, pubmed-meshheading:2261637-Receptors, Interleukin-6, pubmed-meshheading:2261637-Recombinant Proteins, pubmed-meshheading:2261637-Sequence Homology, Nucleic Acid, pubmed-meshheading:2261637-Signal Transduction, pubmed-meshheading:2261637-Transfection
pubmed:year
1990
pubmed:articleTitle
Molecular cloning and expression of an IL-6 signal transducer, gp130.
pubmed:affiliation
Division of Immunology, Osaka University, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't