rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
6
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pubmed:dateCreated |
1991-2-1
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pubmed:databankReference |
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pubmed:abstractText |
Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein, gp130, which associates with IL-6 receptor (IL-6-R). A cDNA encoding human gp130 has been cloned, revealing that it consists of 918 amino acids with a single transmembrane domain. The extracellular region comprises six units of a fibronectin type III module, and part of this region of approximately 200 amino acids has features typical of a cytokine receptor family. A cDNA-expressed gp130 showed no binding property to IL-6 or several other cytokines. Although a transfectant with an IL-6-R cDNA expressed mainly low affinity IL-6 binding sites, an increase in high affinity binding sites was observed after cotransfection with a gp130 cDNA. This confirmed that a gp130 is involved in the formation of high affinity IL-6 binding sites. A cloned gp130 could associate with a complex of IL-6 and soluble IL-6-R and transduce the growth signal when expressed in a murine IL-3-dependent cell line.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
0092-8674
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
21
|
pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1149-57
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2261637-Amino Acid Sequence,
pubmed-meshheading:2261637-Animals,
pubmed-meshheading:2261637-Antibodies, Monoclonal,
pubmed-meshheading:2261637-Antigens, CD,
pubmed-meshheading:2261637-Base Sequence,
pubmed-meshheading:2261637-Cell Division,
pubmed-meshheading:2261637-Cell Line,
pubmed-meshheading:2261637-Cloning, Molecular,
pubmed-meshheading:2261637-Cytokine Receptor gp130,
pubmed-meshheading:2261637-Female,
pubmed-meshheading:2261637-Gene Expression,
pubmed-meshheading:2261637-Gene Library,
pubmed-meshheading:2261637-Humans,
pubmed-meshheading:2261637-Interleukin-6,
pubmed-meshheading:2261637-Membrane Glycoproteins,
pubmed-meshheading:2261637-Molecular Sequence Data,
pubmed-meshheading:2261637-Placenta,
pubmed-meshheading:2261637-Pregnancy,
pubmed-meshheading:2261637-Receptors, Immunologic,
pubmed-meshheading:2261637-Receptors, Interleukin-6,
pubmed-meshheading:2261637-Recombinant Proteins,
pubmed-meshheading:2261637-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2261637-Signal Transduction,
pubmed-meshheading:2261637-Transfection
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pubmed:year |
1990
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pubmed:articleTitle |
Molecular cloning and expression of an IL-6 signal transducer, gp130.
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pubmed:affiliation |
Division of Immunology, Osaka University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|