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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1991-1-29
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pubmed:abstractText |
Pradimicin FA-1 was produced via directed biosynthesis with substitution of D-serine for D-alanine in the 15-position of pradimicin A. This substitution was achieved by the addition of D-serine to the culture medium of Actinomadura hibisca P157-2. Likewise, pradimicin FA-2 was co-produced along with pradimicin FA-1 when the pradimicins A and C producing strain, A. hibisca A2493 was grown in D-serine-supplemented medium. The new pradimicin analogs share a common core structure of 5,6-dihydrobenzo[a]naphthacenequinone substituted by D-serine at C-15, but differ in the disaccharide moiety at C-5. Pradimicin FA-1 has an N-methylamino sugar and D-xylose. Pradimicin FA-2 is the des-N-methyl analog of pradimicin FA-1. The in vitro and in vivo antifungal activity of the analogs was comparable to that of pradimicin A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1223-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2258322-Amino Acids,
pubmed-meshheading:2258322-Animals,
pubmed-meshheading:2258322-Anthracyclines,
pubmed-meshheading:2258322-Antibiotics, Antineoplastic,
pubmed-meshheading:2258322-Antifungal Agents,
pubmed-meshheading:2258322-Candidiasis,
pubmed-meshheading:2258322-Chromatography, High Pressure Liquid,
pubmed-meshheading:2258322-Chromatography, Thin Layer,
pubmed-meshheading:2258322-Fermentation,
pubmed-meshheading:2258322-Fungi,
pubmed-meshheading:2258322-Magnetic Resonance Spectroscopy,
pubmed-meshheading:2258322-Mice,
pubmed-meshheading:2258322-Mice, Inbred ICR,
pubmed-meshheading:2258322-Molecular Structure,
pubmed-meshheading:2258322-Nocardiaceae
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pubmed:year |
1990
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pubmed:articleTitle |
New antifungal antibiotics pradimicins FA-1 and FA-2: D-serine analogs of pradimicins A and C.
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pubmed:affiliation |
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
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pubmed:publicationType |
Journal Article
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